Neurofilament Light Chain, Serum
Use
This test is used for the measurement of the level of Neurofilament Light Chain in serum.
Special Instructions
Patients should be asked about biotin supplementation, as high doses can interfere with the test results. It is recommended to stop biotin intake at least 72 hours prior to sample collection.
Limitations
The test was developed by Labcorp and has not been FDA cleared or approved. There can be variations in serum NfL measurements among different methods and labs. Direct comparison of values should only be done when using the same fluid source (plasma or serum). Elevations in NfL are not specific to any one disease, potentially occurring in neurodegenerative diseases or following head injury. Lifestyle, demographic, and comorbidity factors, such as exercise, obesity, and chronic diseases, can influence sNfL levels. Measurements also vary with the time of collection due to diurnal variations. There is possible interference in patients with high immunoglobulin G levels, and those with different conditions like stroke, atrial fibrillation, and chronic kidney disease may show higher NfL levels.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 101281-4
- 101281-4
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Red-top tube, gel-barrier tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |