Scleroderma Diagnostic Profile
Also known as: Autoimmune Profile II, Scleroderma
Use
The Scleroderma Diagnostic Profile is used to assist in the diagnosis of scleroderma, an autoimmune disorder characterized by changes in the skin, blood vessels, muscles, and internal organs. It primarily helps in detecting the presence of antinuclear antibodies (ANA) and antiscleroderma-70 (scl-70) antibodies, which are associated with systemic sclerosis. The presence of these antibodies is indicative of autoimmunity and can support the clinical diagnosis when interpreted alongside clinical findings and other laboratory tests.
Special Instructions
Ensure that the specimen is collected in either a red-top tube or gel-barrier tube. Proper handling and storage are essential to maintain specimen integrity. Physicians should make sure to check with the laboratory in case any additional confirmatory tests are necessary, which might affect the overall turnaround time.
Limitations
The test has limitations as it may not detect all forms of scleroderma, and a negative result does not rule out the disease. Additionally, the presence of ANA or scl-70 antibodies may occur in other autoimmune disorders or even in healthy individuals, which may lead to false-positive results. Results should be interpreted in the context of the patient's clinical history and other diagnostic findings. Reflex testing may be needed for accurate diagnosis, which can increase the time required for final results.
Methodology
Other
Biomarkers
LOINC Codes
- 27416-7
- 8061-4
- 8061-4
- 27416-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |