Syphilis: RPR With Reflex to RPR Titer and Treponemal Antibodies, Traditional Screening and Diagnosis Algorithm

Casandra

Casandra Test Code LC97986Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 012005CPT Code 86592

Syphilis: RPR With Reflex to RPR Titer and Treponemal Antibodies, Traditional Screening and Diagnosis Algorithm

Also known as: Nontreponemal Test, Serological Tests for Syphilis (STS), Syphilis Serology

Clinical Use

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Use

This test is intended to support screening and diagnosis of syphilis infections. This test aligns with the CDC-supported traditional serologic testing algorithm for syphilis using a combination of both treponemal and nontreponemal antibody tests. The traditional syphilis testing algorithm begins with the RPR (nontreponemal) test with positive samples reflexing to RPR titer and treponemal antibody testing. Interpretation of results obtained must take into account patient symptoms and clinical history.

Special Instructions

An additional fee is charged when a confirmatory Treponema pallidum test is performed. Interpretation of results obtained must take into account patient symptoms and clinical history, and clinical evaluation should be performed if recent exposure is suspected.

Limitations

Biological false positive results (RPR-reactive, Treponemal antibody-negative) can occur with infections other than syphilis, recent immunizations, autoimmune disorders, pregnancy, and injection drug use. These limitations need to be considered when interpreting the results. If recent exposure is suspected, submitting a new sample for testing in 2-4 weeks is recommended to ensure accuracy.

Test Details