Cytosolic 5’-Nucleotidase 1A (cN‑1A) Antibody (IgG)
Also known as: MUP44 AB, cN1A, sIBM, Inclusion Body Myositis, Anti-IBM
Use
This assay detects autoantibodies against cytosolic 5’-nucleotidase 1A (cN‑1A, also known as NT5C1A), which are highly specific biomarkers for inclusion body myositis (IBM). A positive result strongly supports the diagnosis of IBM, though sensitivity is moderate due to a substantial proportion of false negatives; hence, a negative result cannot exclude IBM entirely. This test serves as a diagnostic aid in distinguishing IBM from other myopathies.
Special Instructions
Not provided.
Limitations
The sensitivity of anti‑cN‑1A autoantibody detection is variable and may miss many cases of IBM, making a negative result insufficient to rule out disease. Different methods (e.g., ELISA, line immunoassay) offer variable performance metrics and lack standardization, affecting comparability across laboratories.
Methodology
Immunoassay (ELISA)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Not provided.