Use

This test detects NS5A resistance-associated variants (RAVs) in genotype 1 hepatitis C virus (HCV), including key codons 28, 30, 31, 58 and 93 (e.g., Y93H), enabling assessment of resistance to NS5A inhibitor direct‑acting antiviral drugs and guiding treatment decisions, particularly for therapy‑naïve genotype 1a patients being considered for NS5A‑containing regimens like elbasvir/grazoprevir or sofosbuvir/ledipasvir. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq173?utm_source=openai))