Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G
Also known as: PAI-1 4G/5G Polymorphism, PAI-1 Promoter Polymorphism, Plasminogen Activator Inhibitor-1, PAI-1 (Plasminogen Activator Inhibitor-1)
Use
This test analyzes the 4G/5G promoter polymorphism in the SERPINE1 gene (PAI‑1), which is associated with altered plasma PAI‑1 levels and risk assessment in thrombophilia and related conditions. It is performed as a germline genetic risk assessment using targeted variant analysis via PCR.
Special Instructions
Not provided.
Limitations
Only the 4G/5G promoter variant is assessed; rare polymorphisms at primer/probe sites may interfere with allele detection, and results should be interpreted alongside clinical data as an aid in risk evaluation.
Methodology
PCR-based (PCR)
Biomarkers
SERPINE1
Gene
LOINC Codes
- 52757-2 - SERPINE1 c.-675 4G+5G Bld/T Ql
- 50398-7 - Narrative diagnostic report-Imp
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
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