Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G
Also known as: PAI-1 4G/5G Polymorphism, PAI-1 Promoter Polymorphism, Plasminogen Activator Inhibitor-1, PAI-1 (Plasminogen Activator Inhibitor-1)
Use
This test analyzes the 4G/5G promoter polymorphism in the SERPINE1 gene (PAI‑1), which is associated with altered plasma PAI‑1 levels and risk assessment in thrombophilia and related conditions. It is performed as a germline genetic risk assessment using targeted variant analysis via PCR.
Special Instructions
Informed consent may be required depending on state law. Ordering is restricted to licensed physicians/health care providers. The test is performed by Quest Diagnostics Nichols Institute San Juan Capistrano.
Limitations
Only the 4G/5G promoter variant is assessed; rare polymorphisms at primer/probe sites may interfere with allele detection, and results should be interpreted alongside clinical data as an aid in risk evaluation.
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 52757-2
- 50398-7
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided