Use

Functional assay used to evaluate patients with suspected heparin‑induced thrombocytopenia (HIT); significant drop in platelet count (>40%) during or after heparin exposure should raise suspicion, and this assay assesses heparin‑dependent platelet activation via antibody‑mediated serotonin release. Ticagrelor may lead to false‑negative results and should be avoided during testing.