Voltage‑Gated Potassium Channel (VGKC) Antibody
Also known as: VGKC
Use
This test screens for voltage‑gated potassium channel (VGKC) complex‑associated autoantibodies, used to evaluate patients for suspected autoimmune neurological disorders such as VGKC antibody‑mediated encephalitis. It cannot distinguish between CASPR2 or LGI1 subtypes but may be useful for follow‑up in antibody‑positive individuals after immunotherapy or plasmapheresis.
Special Instructions
Not provided.
Limitations
Does not distinguish specific target proteins (LGI1, CASPR2) within the VGKC complex; interpretation may require follow‑up testing to further characterize antibody specificity.
New York Approved
Methodology
Immunoassay (Radioimmunoassay)
Biomarkers
Voltage‑Gated Potassium Channel (VGKC) Antibody
Analyte
LOINC Codes
- 41871-5 - VGKC Ab Ser-sCnc
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
0.5 mL
Container
Red Top (no additive) or serum separator tube
Collection Instructions
Collect blood; separate serum from cells within 1 hour of collection
Storage Instructions
Refrigerated (preferred); can be frozen
Causes for Rejection
Plasma; grossly lipemic or icteric specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 Hours |
| Refrigerated | 2 Weeks |
| Frozen | 1 Month |
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