Chimerism, Posttransplant
Also known as: STR_POST
Use
This test is used to monitor chimerism and engraftment in recipients of allogeneic hematopoietic stem cell transplants. It aids in evaluating the relative amounts of recipient and donor cells present post transplant. Accurate monitoring of chimerism levels is vital for understanding how well engraftment is occurring and for guiding potential interventions in the transplant process.
Special Instructions
Each posttransplant specimen and test ordered must have a unique ARUP accession number. Donor and recipient specimens must be obtained and genotyped before the transplant event occurs. The test incorporates both whole blood and bone marrow samples to provide comprehensive results.
Limitations
The test has a limit of detection of 2 percent of minor cell populations. Diagnostic errors can occur due to rare sequence variations. It has not been cleared or approved by the U.S. Food and Drug Administration and is intended for clinical purposes as a laboratory-developed test. Careful correlation with clinical status and consideration of the interval between bone marrow transplantation and testing is necessary for proper interpretation.
New York Approved
Methodology
PCR-based
Biomarkers
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B)
Storage Instructions
Refrigerated. Also acceptable: Ambient.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 month |
| Frozen | Unacceptable |
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