FISH, High‑Grade Lymphoma Panel
Use
High‑grade B‑cell lymphoma can be difficult to classify if histologic and immunophenotypic features are not entirely typical. Large B‑cell lymphoma with monomorphic appearance or very high mitotic rate and Burkitt lymphoma cases that have atypical immunophenotypic or morphologic appearances present diagnostic difficulties. The FISH panel for MYC (8q24), t(14;18) (IGH‑BCL2) and BCL6 (3q27) translocations provides additional diagnostic information that may help in final classification and therapy selection in high‑grade B‑cell lymphomas, as well as to assess for “double‑hit” and “triple‑hit” lymphomas.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL (1 mL minimum)
Minimum Volume
1 mL
Container
transport media or sodium heparin (green‑top, royal blue‑top or tan‑top) tube
Collection Instructions
Bone Marrow: 1‑3 mL in transport medium (preferred) or sodium heparin tube acceptable
Other tests from different labs that may be relevant