Human Immunodeficiency Virus Type 1 (HIV-1) Trofile Co-Receptor Tropism

Casandra

Casandra Test Code AR25210Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3001246CPT Code 87999

Human Immunodeficiency Virus Type 1 (HIV-1) Trofile Co-Receptor Tropism

Also known as: HIV TROFIL

Clinical Use

Order Test

Use

This test is intended for use in patients with viral loads of ≥1,000 copies/mL. It is a phenotyping test that determines the HIV-1 co-receptor tropism (CCR5 or CXCR4) of the virus, which is crucial for selecting appropriate treatment strategies involving CCR5 antagonist therapies. Co-receptor tropism classifications include R5 (CCR5 usage), X4 (CXCR4 usage), or dual/mixed (both CCR5 and CXCR4 usage). The test provides important predictive information relating to the effectiveness of CCR5 antagonists, which are not recommended for individuals with dual/mixed or CXCR4-tropic HIV-1.

Special Instructions

The test is performed by Monogram Biosciences, a subsidiary of Labcorp. It requires a separate specimen submission as ARUP does not perform this test directly. Specimen must be critically frozen and separated from cells within 6 hours of collection. Minimum 3 mL of plasma is required for testing.

Limitations

This test is specifically validated for patients with HIV-1 viral loads equal to or above 1000 copies/mL. It should not be used as the sole criterion for patient management decisions. The performance characteristics of this test have been determined by Labcorp and it has not been cleared or approved by the Food and Drug Administration. The interpretation of the test results should consider comprehensive clinical information beyond the laboratory findings.

Test Details

New York Approved