Sickle Cell Screen with Reflex to Hemoglobinopathy Evaluation
Use
This test performs an initial screening for sickling hemoglobins using a solubility (Sickle Cell) screen, and if positive, reflexes to a comprehensive Hemoglobinopathy Evaluation to identify and quantify hemoglobin variants. Intended for use in diagnosing sickle cell trait or disease, particularly when screening for Hemoglobin S or other abnormal hemoglobin variants, and meets requirements such as NCAA screening.
Special Instructions
Patient age and ethnicity are necessary for proper interpretation; not appropriate for patients under 6 months due to interference by Hemoglobin F. Maintain specimen at room temperature; do not centrifuge. Whole blood in EDTA tube is required; awareness of recent blood transfusion (within last 4 months) may affect results.
Limitations
High levels of Hemoglobin F (as in patients under 6 months) may interfere with results; recent blood transfusion (within 4 months) may affect interpretation.
Methodology
Other
Biomarkers
Result Turnaround Time
0 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
1 mL
Container
EDTA (lavender‑top) tube; alternate acceptable: tan‑, pink‑, or royal blue‑top EDTA tubes
Storage Instructions
Maintain at room temperature; do not centrifuge
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