Syphilis: Treponemal Antibodies With Reflex to RPR and RPR Titer, Reverse Screening and Diagnosis Algorithm

Casandra

Casandra Test Code LC03215Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 082345CPT Code 86780

Syphilis: Treponemal Antibodies With Reflex to RPR and RPR Titer, Reverse Screening and Diagnosis Algorithm

Also known as: Syphilis, Trep-Sure™, Treponemal

Clinical Use

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Use

This test is intended to support screening and diagnosis of syphilis infections. This test aligns with the CDC-supported reverse serologic testing algorithm for syphilis using a combination of both treponemal and nontreponemal antibody tests. The reverse syphilis testing algorithm begins with a treponemal antibody assay. Positive samples reflex to RPR (nontreponemal). If the RPR is positive, RPR titer will be determined. If the RPR is negative, a second treponemal antibody assay will be performed to confirm the presence of treponemal antibodies. Interpretation of results obtained must take into account patient symptoms and clinical history.

Special Instructions

N/A

Limitations

Treponemal antibodies tend to persist for life despite treatment, making this assay unsuitable for monitoring response to treatment or assessing treatment outcomes. False-positive results can occur in individuals with non-syphilis treponemal infections like bejel, pinta, and yaws.

Test Details