Anti-sp100 and anti-gp210 Antibodies, IgG
Also known as: SP100GP210
Use
This test is recommended for the evaluation of individuals with suspected primary biliary cholangitis (PBC) who test negative for anti-mitochondrial antibodies (AMA). Anti-gp210 and anti-sp100 antibodies can be detected in patients with PBC and may be of diagnostic relevance in a subset of these patients. The antibodies have relatively low sensitivity but excellent specificity for PBC, and a negative result does not rule out PBC.
Special Instructions
Not provided.
Limitations
While the test is specific for primary biliary cholangitis (PBC), it is limited by its relatively low sensitivity. This means that a negative result does not completely rule out the possibility of PBC in patients, especially those who might otherwise meet clinical criteria. Repeated freeze/thaw cycles of samples should be avoided as they might compromise test results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 96560-8 - Nuclear pore prot gp210 Ab Ser IA-aCnc
- 96565-7 - sp100 Ab Ser IA-aCnc
- 96560-8 - Nuclear pore prot gp210 Ab Ser IA-aCnc
- 96565-7 - sp100 Ab Ser IA-aCnc
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.0 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Collect using a serum separator tube (SST) and separate from cells as soon as possible or within 2 hours of collection.
Storage Instructions
Store and transport refrigerated.
Causes for Rejection
Nonserum, heat-inactivated, contaminated, grossly icteric, severely lipemic, grossly hemolyzed specimens, or inclusion of fibrin clot.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant