Anti-sp100 Antibody, IgG
Also known as: SP100 AB
Use
Anti-sp100 IgG antibodies are used in the evaluation of individuals with suspected primary biliary cholangitis (PBC), particularly in cases where the patients test negative for anti-mitochondrial antibodies (AMA). These antibodies are of diagnostic relevance due to their relatively low sensitivity but excellent specificity for PBC. Despite this, a negative result does not rule out the disease, highlighting the antibodies' role in identifying a subset of patients with PBC who are AMA-negative.
Special Instructions
Not provided.
Limitations
The Anti-sp100 Antibody, IgG test possesses low sensitivity, which means it may not detect all cases of PBC, particularly in patients without anti-sp100 antibodies. However, the specificity is high, indicating that positive results are strongly indicative of PBC. The test cannot replace AMA testing but complements it by assisting in diagnosing AMA-negative patients. Correct interpretation requires consideration of clinical findings and other diagnostic tests.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Anti-sp100 Antibody, IgG
Antibody
LOINC Codes
- 96565-7 - sp100 Ab Ser IA-aCnc
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.1 mL
Container
ARUP standard transport tube
Collection Instructions
Collect using a Serum Separator Tube (SST). Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated
Causes for Rejection
Non-Serum, heat-inactivated, contaminated, grossly icteric, severely lipemic, grossly hemolyzed specimens, or inclusion of fibrin clot.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (avoid repeated freeze/thaw cycles) |
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