Aspergillus Galactomannan Antigen by EIA, Serum

Casandra

Casandra Test Code AR40460Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0060068CPT Code 87305

Aspergillus Galactomannan Antigen by EIA, Serum

Also known as: ASPERAG

Clinical Use

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Use

The Aspergillus Galactomannan Antigen by EIA, Serum test aids in the diagnosis of invasive or disseminated aspergillosis. This test is used as a diagnostic aid in patients suspected of having invasive aspergillosis, particularly in high-risk patients where early detection is critical. It involves measuring the presence of galactomannan, a molecule found in the fungal cell wall of Aspergillus species, and helps in the identification of fungal infections which could be life-threatening in immunocompromised individuals.

Special Instructions

For precise detection, it is vital to correlate single positive results with additional serum specimen testing due to potential cross-reactivity with other agents like antibiotics or certain foods. Serial sampling is recommended for suspected cases of invasive aspergillosis in high-risk patients. The test uses a semi-quantitative enzyme immunoassay methodology and is scheduled to be performed every day of the week, providing a rapid turnaround with results typically reported within 1 to 2 days.

Limitations

Negative results do not rule out the possibility of invasive aspergillosis, and further testing should be considered, especially in high-risk or symptomatic patients. Single positive test results require correlation with additional clinical findings and possibly a repeat test due to potential cross-reaction with non-fungal substances like certain foods and antibiotics. False positives are more common in children compared to adults, affecting the reliability of results in pediatric populations. Additionally, plasma and hemolyzed specimens are unacceptable and may lead to test errors.

Test Details

FDA Approved