Cardiolipin Antibodies, IgG and IgM
Also known as: ANTI-CARD
Use
This test assists in the diagnosis of antiphospholipid syndrome (APS) and is applicable when APS is strongly suspected. The persistent presence of IgG and/or IgM cardiolipin antibodies in moderate or high levels (greater than 40 GPL and/or MPL units) is a laboratory criterion for APS diagnosis. Persistence is defined as detection in two or more specimens drawn at least 12 weeks apart. Lower positive levels may occur in patients with APS symptoms, but their significance is undefined. Results should be interpreted in conjunction with APS clinical manifestations and other phospholipid antibody tests.
Special Instructions
Order with Lupus Anticoagulant Reflex Panel and Beta-2 Glycoprotein 1 Antibodies to provide comprehensive APS testing.
Limitations
The results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests. Lower positive levels of antibodies than the defined cutoff do not conclusively indicate APS.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 3181-5
- 3182-3
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |