Coccidioides Antibodies, IgM and IgG by Immunoassay, Serum
Also known as: COCCI G/M
Use
This test is designed to screen for the presence of coccidioidal IgM and IgG antibodies in serum, aiding in the diagnosis of Valley Fever (Coccidioidomycosis). Coccidioidomycosis is an infectious disease caused by inhaling the spores of the fungus Coccidioides. IgM and IgG antibodies serve as biomarkers for detecting current or past infections. IgG antibody typically appears by the third week of infection and may persist for years, whereas IgM antibody usually appears by the second week and disappears by the fourth month. This test is not recommended as a standalone diagnostic tool and should be part of a comprehensive panel for accurate diagnosis.
Special Instructions
Not provided.
Limitations
This test uses recombinant and native Coccidioides antigens, including CF and TP antigens. False negatives may occur if antibodies are present at levels below the detection limit, or if the infection has only recently been contracted, as antibody production may not be sufficient. False positives may also occur due to cross-reactivity with other fungal infections or due to technical errors in sample handling or processing. The test should not be the sole basis for diagnosis and must be interpreted in conjunction with clinical findings and other diagnostic procedures.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
Coccidioides Antibody, IgG
ProteinCoccidioides Antibody, IgM
Protein
LOINC Codes
- 90448-2 - Coccidioides IgM SerPl-aCnc
- 27009-0 - Coccidioides IgG Ser-aCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.6 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in Serum Separator Tube (SST), separate from cells ASAP or within 2 hours.
Causes for Rejection
Other body fluids; contaminated, hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
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