Cryptococcus Antigen, Serum
Also known as: CRY BLD
Use
This test is used to identify Cryptococcus neoformans as the infectious agent causing invasive cryptococcal disease. The detection of cryptococcal antigen in serum can assist in the diagnosis of cryptococcal infections, which are often life-threatening, especially in individuals with weakened immune systems such as those with HIV/AIDS. This test helps in guiding clinical decision-making and managing antifungal therapy.
Special Instructions
Positive specimens are titered to determine the levels of antigen present, which may provide insight into the severity of infection. It's important to separate serum from cells as soon as possible or within 2 hours of collection to ensure accurate test results. Proper storage and transport conditions should be maintained to preserve specimen integrity.
Limitations
A negative result does not rule out the possibility of cryptococcal infection. False positives may occur, and other causes of antigenemia should be considered. The test is intended to support the diagnosis of invasive cryptococcal disease, but it should be used in conjunction with clinical findings and other laboratory tests. In certain clinical conditions, repeat testing or further investigation might be necessary to confirm the diagnosis.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Enzyme Immunoassay)
Biomarkers
LOINC Codes
- 29903-2
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.25 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect the specimen in a plain red or serum separator tube (SST). Separate serum from cells as soon as possible or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma specimens are not acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 hour |
| Refrigerated | 1 week |
| Frozen | 1 week |