Echovirus Antibodies
Also known as: ECHO
Use
This test is used to detect neutralizing antibodies for echovirus types 6, 7, 9, 11, and 30. The presence of these antibodies, especially when titer levels are greater than or equal to 1:80, may indicate a past or current echovirus infection. Seroconversion or a fourfold increase in antibody titers between acute and convalescent serum samples is considered strong evidence of a current or recent infection.
Special Instructions
PCR testing is preferred for diagnosing acute echovirus infection. It is important to mark samples clearly as 'acute' or 'convalescent' and ensure that convalescent samples are received within 30 days from the collection of acute samples.
Limitations
This test is limited to detecting neutralizing antibodies for the specified echovirus types: 6, 7, 9, 11, and 30. It cannot differentiate between past and current infections solely based on a positive result; clinical correlation and further testing, such as PCR, may be necessary for acute diagnosis. The test is not suitable for identifying other echovirus types or any other viral infections. Also, false positives may occur due to cross-reactivity with other enteroviruses or in individuals previously vaccinated or exposed. Additionally, conditions like hemolysis, lipemia, or contamination can compromise specimen integrity, rendering them unacceptable.
New York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 5144-1
- 41492-0
- 41489-6
- 41491-2
- 5146-6
Result Turnaround Time
6-12 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells as soon as possible or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. Ensure convalescent samples are received within 30 days from receipt of acute samples.
Storage Instructions
Refrigerated
Causes for Rejection
CSF or plasma; Contaminated, hemolyzed, or severely lipemic specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |