Coxsackie A Virus Antibody Profile, IgG
Also known as: Hand, Foot, and Mouth Disease
Use
This assay uses indirect immunofluorescence to determine IgG titers to Coxsackie A serotypes A7, A9, A16, and A24. Recent infections of Coxsackie viruses are characterized by elevated titers of IgG and IgM.
Special Instructions
Coxsackie A is commonly associated with hand, foot, and mouth disease. Results from Coxsackie A serologies should correlate with patient's clinical history and available data. If a recent infection is suspected, a second specimen should be collected 10 to 20 days after the initial collection.
Limitations
A positive test result does not necessarily indicate a current or recent infection as antibodies can be detected in uninfected individuals due to moderate passive exposure. Early stage samples, especially in children, may not yield detectable antibodies. Reliance solely on this test without correlating clinical history may mislead diagnosis.
Methodology
Immunoassay (Indirect immunofluorescence)
Biomarkers
LOINC Codes
- 59584-3
- 58792-3
- 59583-5
- 59582-7
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Gel-barrier tube or red-top tube
Storage Instructions
Room temperature
Causes for Rejection
Microbially-contaminated or heat-treated specimen; specimen containing particulate matter; grossly hemolyzed, lipemic, or icteric samples
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |