Growth Hormone, 60 Minutes
Also known as: GH 60
Use
The Growth Hormone, 60 Minutes test is used for the evaluation of growth hormone deficiency (GHD) and acromegaly in both pediatric and adult patients. In pediatric patients, very low peak growth hormone concentrations on stimulation testing are indicative of severe GHD. For adults, expected peak GH concentrations vary based on the specific stimulation test administered, as guided by endocrinology guidelines. The test also aids in suppression testing, where healthy individuals show GH concentrations of less than 1 ng/mL upon glucose intake, while patients with acromegaly do not exhibit normal suppression.
Special Instructions
The test is standardized to the Recombinant Second International Standard (IS): 98/574, which results in GH readings approximately 25% lower than previous standards. Reference ranges have been modified accordingly. Specimen should be clotted completely at room temperature before separation and transport.
Limitations
Thresholds to differentiate normal from partial GHD have not been well established. Diagnosis of GHD requires inadequate response to two separate provocative tests.
FDA ApprovedNew York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 14146-5
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.4 mL
Container
Plasma separator tube or serum separator tube
Collection Instructions
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer to ARUP Standard Transport Tubes.
Causes for Rejection
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 2 months |