Itraconazole, Quantitative by LC-MS/MS
Also known as: ITRACONAZ
Use
Itraconazole is an azole antifungal drug indicated to treat fungal infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of itraconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by cytochrome P450 3A4 enzyme. Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 ug/mL. Adverse effects may include nausea, abdominal pain, and congestive heart failure.
Special Instructions
Timing of specimen collection: Pre-dose (trough) draw at steady state concentration. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube.
Limitations
No specific therapeutic range has been established for hydroxyitraconazole. The test results can be affected by the timing of the specimen draw, especially with respect to steady-state concentration. Drug-drug interactions, especially with drugs metabolized by cytochrome P450 3A4 enzyme, can influence itraconazole levels, necessitating careful monitoring.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 10989-2
- 18337-6
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.6 mL
Container
Transfer to an ARUP Standard Transport Tube.
Collection Instructions
No specific patient preparation. Timing of specimen collection: Pre-dose (trough) draw at steady state concentration. Separate from cells ASAP or within 2 hours of collection.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Frozen.
Causes for Rejection
Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | 6 months |