LANGERIN by Immunohistochemistry
Also known as: LANGER IHC
Use
Langerin (CD207) immunohistochemical staining is performed to identify Langerin protein expression, a highly selective marker for Langerhans cells, including lesional cells of Langerhans cell histiocytosis. It aids in distinguishing Langerhans cell histiocytosis from other histiocytic proliferations.
Special Instructions
The test is performed as a stain-and-return (technical-only) service. It operates Monday through Friday and requires referral to the ARUP Immunohistochemistry Stain Offerings brochure for ordering recommendations and interface map details. Slides must be positively charged (min: 2) and blocks/slides must be protected from excessive heat. If sending precut slides, do not oven bake. A tissue transport kit (ARUP supply #47808) is recommended but not required.
Limitations
This test was developed and validated by ARUP Laboratories and has not been cleared or approved by the US Food and Drug Administration; it is offered as a laboratory-developed test (LDT). It is intended for clinical purposes and must be interpreted cautiously in the absence of FDA clearance.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3‑ to 5‑micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808 recommended). If sending precut slides, do not oven bake.
Storage Instructions
Protect paraffin block and/or slides from excessive heat. Ship in cooled container during summer months.
Causes for Rejection
Specimens submitted with non‑representative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient: Indefinitely |
| Refrigerated | Refrigerated: Indefinitely |
| Frozen | Frozen: Unacceptable |