Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A
Also known as: MS INT2
Use
This test is a second-trimester screening for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects. It requires a first-trimester specimen to be submitted previously. The test calculates the risk of these conditions by analyzing serum markers from both the first and second trimesters, with or without first-trimester nuchal translucency measurements.
Special Instructions
Ensure specimen is drawn between 14 weeks and 24 weeks, 6 days of gestation. The recommended period for screening is between 16 to 18 weeks of gestation. This test requires a prior first trimester specimen submission (ARUP test code 3000147).
Limitations
This test was developed by ARUP Laboratories and its performance characteristics have been determined in a CLIA certified lab. It is not FDA cleared or approved. The test is not intended to be definitive; positive results should be followed by genetic counseling, level II fetal ultrasound, and possibly amniocentesis if clinically indicated.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 1834-1
- 11778-8
- 35738-4
- 23883-2
- 20450-3
- 49586-1
- 19151-0
- 21299-3
- 44877-9
- 8670-2
- 21484-1
- 11878-6
- 21612-7
- 2250-9
- 20466-9
- 12146-7
- 32123-2
- 49089-6
- 49088-8
- 34970-4
- 49035-9
- 32435-0
- 48407-1
- 64234-8
- 11957-8
- 11526-1
- 19080-1
- 20465-1
- 29463-7
- 18185-9
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect specimen in a Serum Separator Tube (SST) or Plain Red tube. Separate from cells as soon as possible or within 2 hours of collection.
Patient Preparation
Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for screening is 16 to 18 weeks of gestation.
Causes for Rejection
Plasma and hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (Avoid repeated freeze/thaw cycles.) |