Oncology FISH Analysis - Eosinophilia FISH Panel
Use
Oncology FISH Analysis - Eosinophilia FISH Panel is a Fluorescence In Situ Hybridization (FISH) test designed to detect common chromosomal abnormalities associated with eosinophilic cancers. This test is essential for identifying genetic alterations in myeloid and lymphoid neoplasms with eosinophilia, such as chronic eosinophilic leukemia (CEL) and acute myeloid leukemia (AML). It plays a crucial role in diagnostic and prognostic evaluations, guiding treatment decisions, and assessing patient outcomes. Results should be interpreted alongside clinical and pathological data.
Special Instructions
Testing is indicated for patients with clinical or suspected diagnoses of myeloid and lymphoid neoplasms. It is essential when cytogenetic testing is inadequate or for prognostic evaluation. Proper handling and shipping of specimens are crucial to ensure accurate results.
Limitations
This FISH assay only detects translocations involving specific loci, including FIP1L1, CHIC2, PDGFRA, and others. Other chromosomal alterations outside these loci may not be identified, and the absence of abnormalities should not preclude clinical interpretations of adverse conditions.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc (Adults/Children) or 2 cc (Infant <2 years)
Minimum Volume
3 cc
Container
Sodium Heparin (green-top) tube
Collection Instructions
Draw bone marrow in a Sodium Heparin tube.
Storage Instructions
Ship at ambient temperature.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hrs |