Anti-Chromatin Ab, IgG (RDL)
Also known as: Chromatin, Chromatin Ab
Use
Chromatin is comprised of native DNA wrapped around the (H2A-H2B-H3-H4)2 histone octamer, with histone H1 and some non-histone proteins associated. The presence of chromatin antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of drug-induced lupus (DIL) and Systemic Lupus Erythematosus (SLE).
Special Instructions
The test is also a component of ANA 12 Profile, ANA 12 Plus Profile, and Autoimmune Liver Disease Profile. Additional time may be needed for confirmatory or reflex tests. To avoid delays, submit separate frozen specimens for each requested test when multiple tests are ordered on frozen samples.
Limitations
The test's limitations are not explicitly detailed, but false positives or negatives cannot be ruled out due to interfering substances such as hemolysis, lipemia, and icterus. Grossly hemolyzed, bacterial contaminated, lipemic, or icteric specimens, and non-serum specimen types are causes for rejection.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32580-3
- 32580-3
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |