Anti-Contactin-Associated Protein-2 (CASPR2), Spinal Fluid
Also known as: Autoimmune Dementia Panel Spinal Fluid, Paraneoplastic
Use
Anti-Contactin-associated protein-2 (CASPR2) IgG antibody may occur as part of the voltage-gated potassium channel (VGKC) complex antibodies. Patients with CASPR2 autoantibodies are very often elderly males. CASPR2 antibody-positive patients often have neuromyotonia or Morvan's syndrome, and some have forms of limbic encephalitis as well as neuropathic pain syndromes. All typically respond to immunotherapy.
Special Instructions
Not provided.
Limitations
This test was developed by Labcorp in accordance with CLIA requirements, but it has not been cleared or approved by the Food and Drug Administration (FDA), which may limit its availability in certain jurisdictions.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
CASPR2 IgG Antibody
Protein
LOINC Codes
- 90820-2 - CASPR2 Ab CSF Ql CBA IFA
- 90820-2 - CASPR2 Ab CSF Ql CBA IFA
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
Sterile plastic tube
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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