Voltage‑Gated Potassium Channel (VGKC) Antibody, CSF
Also known as: VGKC Antibody, V-Gated K+ Channel Antibody
Use
Voltage‑gated potassium channel (VGKC) antibodies detected in cerebrospinal fluid are associated with neuromuscular disorders such as neuromyotonia (Isaacs syndrome), Morvan syndrome, limbic encephalitis, and paraneoplastic neurological syndromes. However, many VGKC‑antibody cases are ultimately linked to antibodies against LGI1 or CASPR2 rather than the potassium channel complex itself. Clinical interpretation requires correlation with patient history and related testing. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/3001387?utm_source=openai))
Special Instructions
Not provided.
Limitations
This is an LDT (Laboratory‑Developed Test) developed and performed by ARUP Laboratories, not approved or cleared by the US FDA. It may cross‑react with non‑channel autoantigens, and cannot differentiate LGI1 or CASPR2 antibodies. Interpretation should incorporate clinical context and follow‑up testing for more specific markers. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/3001387?utm_source=openai))
New York Approved
Methodology
Other
Biomarkers
Voltage‑Gated Potassium Channel
Protein
LOINC Codes
- 68913-3 - VGKC Ab CSF-sCnc
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
4 mL (min: 0.5 mL)
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Storage Instructions
Refrigerated
Causes for Rejection
Plasma; grossly lipemic or icteric specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant