Anti-Liver/Kidney Ab (RDL)
Also known as: Anti-Liver/Kidney Microsomal Ab, LKM-1
Use
The LKM-1 reactivity is characterized by staining of the hepatocyte cytoplasm and the proximal, but not the distal kidney tubules. Patients with AIH, type 2a disease tend to be young, female, have severe disease, have low IgA levels, have a good response to immunosuppressive therapy and are hepatitis C virus (HCV) negative. The major target antigen of LKM-1 antibodies has been identified as cytochrome P450 2D6, a microsomal protein found in the endoplasmic reticulum. LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.
Special Instructions
Not provided.
Limitations
This test has not been cleared or approved by the FDA. Test results may have limited value in conditions without known LKM-1 antibody prevalence. Specimens must not be grossly hemolyzed, bacterially contaminated, lipemic, icteric, or of non-serum type.
Methodology
Immunoassay (ELISA)
Biomarkers
Cytochrome P450 2D6
Protein
LOINC Codes
- 32220-6 - LKM-1 Ab Ser-aCnc
- 32220-6 - LKM-1 Ab Ser-aCnc
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |
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