Creatine Kinase (CK) and Lactate Dehydrogenase (LD), Totals and Isoenzymes
Also known as: CK and LD Isoenzymes, CPK and LDH Isoenzymes, Lactate Dehydrogenase (LD) and Creatine Kinase (CK) Isoenzymes, LD and CK Isoenzymes, LDH and CK Isoenzymes
Use
Evaluation of possible myocardial damage or other cardiac diseases. See individual test descriptions for CK Isoenzymes and LD Isoenzymes.
Special Instructions
Not provided.
Limitations
The test may have limitations due to interference factors such as hemolysis in the sample, prolonged contact of serum with cells, and improper storage conditions. Specifically, creatine kinase may be affected by hemolysis whereas lactate dehydrogenase is affected by hemolysis and prolonged serum contact. Additionally, Macro CK Type 1 interference can lead to false positives in myocardial infarction diagnosis using CK-MB owing to antibody-related reactions.
Methodology
Other
Biomarkers
LOINC Codes
- 2157-6 - CK SerPl-cCnc
- 2157-6 - CK SerPl-cCnc
- 26020-8 - CK Macro2 CFr SerPl
- 15049-0 - CK MM CFr SerPl Elph
- 26019-0 - CK Macro1 CFr SerPl
- 12187-1 - CK MB CFr SerPl Elph
- 15048-2 - CK BB CFr SerPl Elph
- 14804-9 - LDH SerPl L to P-cCnc
- 2536-1 - LDH1 CFr SerPl Elph
- 2539-5 - LDH2 CFr SerPl Elph
- 2542-9 - LDH3 CFr SerPl Elph
- 2545-2 - LDH4 CFr SerPl Elph
- 2548-6 - LDH5 CFr SerPl Elph
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL refrigerated serum and 3 mL room temperature serum
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Storage Instructions
Creatine kinase: refrigerate. Lactate dehydrogenase: maintain specimen at room temperature. Do not freeze or refrigerate. Creatine kinase: stable refrigerated for 48 hours or frozen for two weeks. Lactate dehydrogenase: stable at room temperature for seven days or refrigerated for no more than three days.
Causes for Rejection
Creatine kinase: hemolysis. Lactate dehydrogenase: hemolysis; prolonged contact of serum with red cells; frozen specimen; specimen refrigerated more than three days after collection at time of testing.
Other tests from different labs that may be relevant