Hemoglobin (Hb) A1c With GlycoMark® Reflex

Also known as: Hb A1c With GlycoMark® Reflex

Clinical Use

Use

GlycoMark® testing provides an estimate of the patient's postmeal glucose over a one- to two-week period, making it ideal for intermediate term monitoring of glycemic control in diabetic patients. GlycoMark® testing can also help monitor the effectiveness of therapeutics targeting postprandial glucose (PPG),1,2 and it is a useful adjunct to routine A1c testing because it responds more rapidly and sensitively to hyperglycemia than A1c.1,2

Special Instructions

Not provided.

Limitations

Individuals using INVOKANA® may demonstrate low levels of 1,5-AG. 1,5-AG blood levels are falsely lowered by the diabetes drug INVOKANA® which prevents reabsorption of 1,5-AG in the kidneys. Persistently positive urinary glucose levels, or oxyhyperglycemia after gastrectomy, may result in low 1,5-AG values. Low values have also been observed in pregnancy, terminal stage renal failure, dialysis patients, advanced cirrhosis, and prolonged incapability of oral ingestion of food. Abnormal values have also been noted in individuals with abnormal glomerular filtration rates. For some patients with severe hyperglycemia, the internal pool of 1,5-AG may tend to remain depleted as a result of persistent glucosuria. 1,5-AG values may be increased when certain Chinese medicines are administered or during intravenous hyperalimentation, and may be lower in patients undergoing therapy with steroids.

Test Details