Casandra
Casandra Test Code LC98907Version 1 (DRAFT)
Performing Lab
Lab LabcorpLab Test ID 550325
Hepatitis C Virus (HCV) NS5A Drug Resistance Assay (GT1a/1b)
Also known as: HCV Drug Resistance, NS5A Resistance Analysis
Clinical Use
Order TestUse
Assessment of drug susceptibility by nucleic acid sequencing of a patient's hepatitis C virus (HCV) to the NS5A inhibitors. Assay should be used for patients with documented HCV genotype 1.
Special Instructions
Not provided.
Limitations
This assay requires an HCV genotype of 1a or 1b and is not successful when the viral load is below approximately 500 IU/mL. Detection of resistance variants may be limited under that threshold.
Test Details
Methodology
NGS
Biomarkers
Next-generation sequencing of the HCV NS5A genomic region to detect amino acid substitutions associated with resistance.
NS5A region
OtherSNV/Indel • Mutation • Categorical (e.g., Positive / Negative / Indeterminate)
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Plasma
Volume
2 mL
Minimum Volume
Not provided
Container
EDTA or PPT tube
Collection Instructions
Collect plasma, ship frozen