Isocyanates Profile
Use
Exposure to isocyanates is associated with various health issues, most notably asthma, chemical bronchitis, hypersensitive pneumonitis, chronic pulmonary disease, and contact dermatitis upon direct skin contact. Quantitative allergen-specific IgE testing via the Isocyanates Profile allows for the monitoring of workplace exposure to isocyanates through the measurement of acid isocyanate-specific IgE levels. Elevated specific IgE levels correlate with increased exposure to isocyanates, which are widely used in industrial processes such as the production of plastics, foams, and coatings.
Special Instructions
Not provided.
Limitations
The test detects IgE antibodies specific to isocyanates and is intended for the assessment of occupational exposure. It may not detect other forms of sensitivity or allergic responses. Additionally, the presence of IgE does not equate to clinical sensitivity, and results should be interpreted in the context of the patient's clinical history and other diagnostic findings. False positives or negatives can occur and may be influenced by concurrent conditions or medications.
Methodology
Immunoassay (Thermo Fisher ImmunoCAP®)
Biomarkers
Hexamethylene diisocyanate (HDI)-specific IgE
AnalyteMethylene diphenyl diisocyanate (MDI)-specific IgE
AnalyteToluene diisocyanate (TDI)-specific IgE
Analyte
LOINC Codes
- 7431-0 - Isocyanate TDI IgE Qn
- 7430-2 - Isocyanate MDI IgE Qn
- 7429-4 - Isocyanate HDI IgE Qn
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Other tests from different labs that may be relevant