Lipid Cascade With Reflex to Apolipoprotein B
Use
The Lipid Cascade with Reflex to Apolipoprotein B test is primarily used to evaluate lipid profiles, aiding in the assessment of cardiovascular disease risk. It measures key lipids in the blood such as total cholesterol, HDL cholesterol, LDL cholesterol, non-HDL cholesterol, and triglycerides. Reflex testing is performed based on initial results to ensure a thorough evaluation. This test is essential for diagnosing and managing dyslipidemias and for monitoring effectiveness of lipid-lowering therapies.
Special Instructions
Fasting for at least eight hours is required before specimen collection. Reflex testing involves additional charges if triglyceride levels exceed 800 mg/dL, which prompts a reflex to direct LDL, and subsequent testing to apolipoprotein B if LDL is below 130 mg/dL.
Limitations
The calculation of LDL cholesterol is not performed if triglyceride levels are above 800 mg/dL, necessitating a reflex to direct LDL measurement. Results are influenced by improper specimen storage or handling, such as hemolysis, which is a cause for rejection. Interpretation requires consideration of fasting status, and variability may occur with different testing schedules.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 363676
- 2093-3
- 2085-9
- 11054-4
- 43396-1
- 2571-8
- 13457-7
- 8251-1
- 18262-6
- 1884-6
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube
Collection Instructions
Separate serum or plasma from cells within 45 minutes of collection.
Patient Preparation
Patient should be fasting for eight hours.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Hemolysis