Lipid Panel With GlycA (Inflammation)
Use
As an (1) aid in the identification and stratification of individuals at risk for future cardiovascular (CV) disease, (2) independent marker of prognosis for recurrent cardiovascular events in patients with stable coronary disease or acute coronary syndrome, (3) aid in the assessment of disease activity and risk of CV disease in adult Rheumatoid Arthritis (RA) and psoriasis patients, when used in conjunction with standard clinical assessment and for monitoring of anti-inflammatory treatment.
Special Instructions
The NMR method for Triglycerides is not affected by endogenous glycerol, which might be found in conditions such as Hyperglycerolemia (glycerol kinase deficiency-GKD), providing more accurate results for such conditions.
Limitations
If the triglyceride level is greater than 800 mg/dL, LDL cholesterol will not be calculated. GlycA measurements from EDTA plasma specimens are 3% to 5% lower than from serum, and NMR LipoTube specimens are 5% to 6% higher. GlycA should not be interpreted without a complete clinical history, as elevated levels may occur due to inflammation, infections, or tissue injury. Hemolysis can reduce GlycA concentrations by more than 10%.
Methodology
Other
Biomarkers
LOINC Codes
- 2093-3
- 2571-8
- 2085-9
- 43396-1
- 13457-7
- 82730-3
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plain red-top tube (preferred); NMR LipoTube (black-and-yellow-top tube), lavender-top (EDTA-no gel) tube or green-top (heparin-no gel) tube is acceptable
Collection Instructions
Collect specimen in plain red-top tube. Allow to clot for 45 minutes at room temperature, centrifuge, then transfer to transport tube for refrigeration.
Patient Preparation
Fasting not required; for conditions where triglyceride levels are critical, a 12-14 hour fast is recommended.
Storage Instructions
Refrigerate at 2°C to 8°C until shipped.
Causes for Rejection
Unspun LipoTube or unseparated plain red-top or EDTA tube; specimen drawn in gel-barrier tube other than NMR LipoTube; hemolysis.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |