Plasminogen Antigen

Clinical Use

Use

Measurement of plasminogen in plasma; may be useful in the distinction between type 1 and type 2 plasminogen deficiency.

Special Instructions

Not provided.

Limitations

Samples must be properly collected and handled to prevent any pre-analytical errors that can affect coagulation assays. The accuracy of the test can be compromised if the blood to anticoagulant ratio is not maintained correctly or if the plasma separation is not handled properly. Improper storage and multiple freeze-thaw cycles can also impact the test results. The test is not suitable for detection of other plasma proteins or coagulation factors.

Test Details

Methodology

Immunoassay (Nephelometry)

Biomarkers

Plasminogen Antigen

Analyte

Plasminogen Antigen

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Result Codes

4668-0 - PLG Ag PPP-mCnc

Result Turnaround Time

3-5 days

Specimen

Plasma

Volume

2 mL

Minimum Volume

1 mL

Container

Blue-top (sodium citrate) tube

Collection Instructions

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times. A discard tube is not required prior to collection of coagulation samples, except when using a winged blood collection device; in which case a discard tube should be used. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette, without disturbing the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Use a second plastic pipette to remove the plasma, staying clear of the platelets at the bottom of the tube. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap (Labcorp No. 49482). Freeze immediately and maintain frozen until tested.