SNP Microarray−Products of Conception (POC)/Tissue (Reveal®)
Also known as: Reveal® SNP Microarray−Products of Conception (POC)/Tissue
Use
This test will detect chromosomal imbalance that could be associated with developmental delay/congenital anomalies. It provides possible detection of uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent. It will also allow the detection of complete or partial molar pregnancies.
Special Instructions
Not provided.
Limitations
The test cannot determine genotypes from some formalin-fixed tissues, restricting analysis to genomic dosage. It does not detect balanced chromosomal rearrangements, mosaicism under 10%, or marker chromosomes comprising only heterochromatin or tetraploidy. The test is also unable to assess DNA alterations below specific copy-number thresholds (>1 Mb for deletions, >2 Mb for duplications).
Methodology
Microarray
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 96984-0 - Chrom analy POC Microarray
- 31208-2 - Specimen source
- 48000-4 - Chromosome Bld/T
- 62365-2 - Diagnostic imp Spec-Imp
- 48672-0 - Clinical cytogeneticist Spec
Result Turnaround Time
12-18 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
>8 mg tissue
Minimum Volume
Not provided
Container
Sterile tube with sterile Ringer's lactate, Hanks' balanced salt solution, or Labcorp transport medium
Collection Instructions
Aseptically obtain a small piece of tissue with subepidermal layers. Optimal results from placental villi. Avoid gross contamination and necrotic tissue.
Storage Instructions
Maintain specimen at room temperature, refrigerate if delayed. Do not freeze.
Causes for Rejection
Cytogenetics lab determines specimen suitability upon receipt.
Other tests from different labs that may be relevant