Soluble Liver Antigen (SLA) IgG Antibody
Also known as: SLA, IgG Antibody
Use
Aid in the diagnosis of autoimmune hepatitis (AIH)1-4
Special Instructions
If a red-top tube is used for serum collection, transfer the separated serum to a plastic transport tube. Ensure compliance with stability requirements and avoid using nonserum specimens, specimens in azide or other preservatives, microbially-contaminated specimens, or heat-treated specimens. Avoid gross lipemia or hemolysis as these will lead to rejection.
Limitations
A negative SLA IgG result does not rule out autoimmune hepatitis as there is no single diagnostic test for the condition. Autoimmune hepatitis diagnosis involves clinical laboratory assessment and histological findings with the exclusion of other chronic hepatitis causes. Detection is particularly challenging in patients with cryptogenic hepatitis who do not present with conventional autoimmune markers. The exact function and role of anti-SLA/LP autoantibodies remain unclear, although they are associated with increased AIH severity.
Methodology
Immunoassay (EIA)
Biomarkers
LOINC Codes
- 38420-6
- 38420-6
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.6 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
If red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Room temperature
Causes for Rejection
Nonserum specimen received; specimen in azide or other preservative; microbially-contaminated specimen; heat-treated specimen; gross lipemia or hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |