Stiff-Person Disorders Profile, Serum
Also known as: Stiff-Person Spectrum Disorders, Stiff-Person Syndrome
Use
This test is recommended for the assessment of stiff-person disorders, whether they manifest in classical or focal forms. This includes symptoms like stiffness, spasms, hyperekplexia, limb rigidity, myoclonus or limb dystonia, regardless of the presence or absence of encephalopathy.
Special Instructions
Not provided.
Limitations
A negative result doesn't exclude stiff-person spectrum disorder. Interpretation of low GAD65 titers should consider possible connections to other autoimmune conditions causing neurological symptoms. The test is developed and its performance evaluated by Labcorp, but it lacks FDA clearance or approval.
Methodology
Immunoassay (Immunofluorescence, immunoblot)
Biomarkers
LOINC Codes
- 94385-2 - Amphiphysin IgG Ser Ql Line blot
- 94676-4 - DPPX IgG Ser Ql CBA IFA
- 81725-4 - GAD65 Ab Ser Ql Line blot
- 77202-0 - Laboratory comment Report
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube or red-top tube
Collection Instructions
If a tube other than a gel-barrier tube is used, transfer the separated serum to a plastic transport tube. Do not freeze the gel-barrier tube (pour off serum first).
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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