Thyroglobulin, Comprehensive (With Anti-Tg Screen and Reflex to RIA) (Endocrine Sciences)
Also known as: Extended-storage Comprehensive Thyroglobulin (With Anti-Tg Screen and Reflex to RIA)
Use
Comprehensive thyroglobulin can be used to monitor recurrence of thyroid cancer. All specimens are tested for the presence of antithyroglobulin autoantibodies (anti-Tg). Specimens negative for the presence of anti-Tg are reflexed to thyroglobulin testing by ICMA, and specimens positive for the presence of anti-Tg are reflexed to thyroglobulin testing by RIA.
Special Instructions
Specimens are stored frozen for one year, allowing for potential future testing. Orders should consider that reflex testing is contingent on anti-Tg status, requiring appropriate sample handling and transport in a frozen state.
Limitations
The presence of anti-thyroglobulin autoantibodies can interfere with thyroglobulin measurement, necessitating reflex to an alternative assay (RIA) to obtain accurate results. Samples cannot be plasma or grossly hemolyzed. The minimum volume does not allow for repeat testing, which might limit confirmatory analysis if needed.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 57780-9
- 8098-6
- 3013-0
Result Turnaround Time
4-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
5 mL
Minimum Volume
1.5 mL
Container
Gel-barrier tube or red-top tube
Collection Instructions
Transfer specimen to a plastic transport tube before freezing. Serum must be separated from cells within one hour of venipuncture. Submit serum in a plastic transport tube.
Storage Instructions
Freeze. Stable at room temperature for three days or refrigerated for 14 days. Stable when frozen for 3.79 years. Freeze/thaw cycles: stable x2.
Causes for Rejection
Plasma specimen received; gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 days |
| Refrigerated | 14 days |
| Frozen | 3.79 years |