VistaSeq® Endocrine Cancer Panel
Also known as: Familial Cancer testing, Hereditary Cancer testing, Inherited Cancer testing, MEN1, MEN2
Use
This assay is intended for patients with a family history consistent with an inherited cancer syndrome.
Special Instructions
Not provided.
Limitations
The test may not detect variants located in regions outside the covered areas, such as noncoding or deeply intronic regions. Microsatellite and mosaics, along with genomic rearrangements like transposable element insertions, may not be reliably detected. Sequencing may be affected by allele drop-out or homopolymeric regions. Pseudogenes can interfere with detection in certain genes. Del/dup analysis of genes like PMS2 may be complicated by homologous pseudogenes like PMS2CL, which are not associated with Lynch syndrome. Translocations, certain rearrangements, and exact breakpoints of deletions or duplications may not be determined. Additionally, somatic variants are not targeted, and results can be affected by bone marrow transplantation.
Methodology
NGS
Biomarkers
LOINC Codes
- 73977-1 - Cancer multigene analysis Bld/T
- 31208-2 - Specimen source
- 51968-6 - Gene dis anl interp-Imp
- 69548-6 - Genetic var assess
- 47042-7 - Counseling note
- 77202-0 - Laboratory comment Report
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 72486-4 - Lab director name Provider
- 51969-4 - Gene analysis narr rpt Doc
Result Turnaround Time
23-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Blood is collected by routine phlebotomy.
Storage Instructions
Room temperature
Causes for Rejection
Frozen specimen; leaking tube; clotted specimen; grossly or hemolyzed specimen; quantity not sufficient for analysis; incorrect anticoagulant.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 days |
| Refrigerated | 60 days |
Other tests from different labs that may be relevant