Heparin‑Induced Platelet Antibody with Reflex to SRA, Unfractionated Heparin

Casandra

Casandra Test Code QD19572Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 15334CPT Code 86022

Heparin‑Induced Platelet Antibody with Reflex to SRA, Unfractionated Heparin

Also known as: Serotonin Release Assay, Heparin Associated Platelet Ab, Heparin-Induced Thrombocytopenia, HIT

Clinical Use

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Use

Diagnosis of Heparin‑Induced Thrombocytopenia (HIT) is based on clinical criteria; serological confirmation is often necessary. The ELISA measures IgG antibodies against the platelet factor 4/heparin complex, and a reflex to a Serotonin Release Assay (SRA) is performed, which is more predictive of thrombocytopenia and thrombosis when the initial immunoassay is weakly positive or positive. Patients should not be on ticagrelor as it may result in a false‑negative SRA.