Use

The Collagen Binding Activity is a surrogate assay for the measurement of von Willebrand Factor (VWF)‑mediated platelet adhesion. Decreased activity (collagen bound to the A3 domain of the VWF protein) relative to the VWF antigen level is observed with qualitative defects of VWF (type 2 disorders). The CBA assay may assist in the discrimination of type 2 disorders. In addition, there have been reports of isolated defects of CBA as a cause for a variant form of von Willebrand disease. It’s a functional assay detecting VWF adhesive activity to collagen, critical for platelet adhesion and clot formation, and used alongside VWF:RCo and VWF:Ag assays to aid in discrimination of VWD types 1, 2A, 2B, 2M, and 3.