Oncology FISH Analysis - IGH/CCND1: t(11;14) [Mantle Cell Lymphoma]
Use
Oncology FISH Analysis - IGH/CCND1: t(11;14) [Mantle Cell Lymphoma] is designed to detect chromosomal rearrangements associated with mantle cell lymphoma (MCL), an aggressive form of non-Hodgkin's lymphoma (NHL). This assay aids in diagnosis and helps in identifying the presence of a common abnormality, LSI IGH/CCND1: t(11;14). Results should always consider clinical and pathological context, and the test is pivotal for patients suspected of having MCL, especially when other cytogenetic tests have failed.
Special Instructions
The FISH assay is designed for use in patients suspected of having mantle cell lymphoma, especially when cytogenetic testing fails to yield results. This test may also assist in the prognostic identification of anomalies in diagnosed patients and in monitoring therapy responses. It is vital for healthcare providers to understand the implications of these findings in the overall clinical context.
Limitations
This assay is specific for rearrangements involving the IgH and CCND1 loci only. It does not identify alterations involving other chromosomes, which limits its diagnostic scope. Therefore, reliance solely on this test for MCL diagnosis is not advisable without complementary clinical information, given its inability to detect additional partner chromosome rearrangements.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow (Fresh)
Volume
3-5 cc
Minimum Volume
2 cc
Container
Sodium Heparin Tube (Green-Top)
Collection Instructions
Draw bone marrow in a Sodium Heparin tube and send.
Storage Instructions
Ship at ambient temperature.
Causes for Rejection
No tumor in tissue or frozen specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | Acceptable |
Other tests from different labs that may be relevant