Basement Membrane Zone Antibody Panel

Also known as: BMZ AB PAN

Clinical Use

Use

The Basement Membrane Zone Antibody Panel is the preferred initial diagnostic tool for suspected basement membrane zone antibody-associated skin and mucous membrane disorders that present with blistering, erosions, eczema, urticaria, pruritus, and/or mucositis. This panel aids in the diagnosis of pemphigoid, epidermolysis bullosa acquisita, and other related disorders by detecting IgG and IgA antibodies against components of the basement membrane zone using indirect immunofluorescence and ELISA. By providing insights into disease expression and activity, it helps inform patient management and therapy monitoring strategies.

Special Instructions

Not provided.

Limitations

This test does not rule out the diagnosis of associated diseases if negative. Detection, levels, and patterns of antibodies may vary with disease manifestations and do not solely confirm the condition. Clinical correlation with direct immunofluorescence findings and patient treatment history is essential for accurate interpretation. Additionally, the performance characteristics of non-FDA-cleared or approved methodologies utilized in this panel have been determined by the Immunodermatology Laboratory at the University of Utah, and are not intended for FDA clearance.

Test Details

New York Approved

Methodology

Immunoassay (ELISA)

Biomarkers

2 components

Indirect Immunofluorescence Assay • Indirect ImmunofluorescenceELISA • ELISA

LOINC Codes

Order Codes

63566-4 - BM Ab pattern Ser IF-Imp

Result Turnaround Time

3-9 days

Specimen

Serum

Volume

2 mL

Minimum Volume

0.5 mL

Container

ARUP Standard Transport Tube

Storage Instructions

Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.