Desmoglein 1 and Desmoglein 3 (Pemphigus), IgG Antibodies
Also known as: Desmoglein 1 and 3 IgG, Pemphigus Autoantibodies
Use
This test is a preferred screening test for patients suspected to have an autoimmune blistering disorder of the skin or mucous membranes (pemphigus). This test aids in the diagnosis of pemphigus. The antibody levels can be used to monitor the effectiveness of drug treatment.
Special Instructions
Not provided.
Limitations
The stability of serum samples at room temperature and refrigerated conditions is not guaranteed, hence they require freezing at -20°C for prolonged storage. Freeze/thaw cycles should be kept to a minimum (no more than three) to ensure sample integrity. Bacterial contamination, hemolysis, and lipemia can lead to sample rejection, as they may interfere with accurate test results.
Methodology
Immunoassay (Enzyme Immunoassay (EIA))
Biomarkers
Desmoglein 1 IgG
ProteinDesmoglein 3 IgG
Protein
LOINC Codes
- 81201-6 - PLA2R IgG Titr Ser IF
- 94336-5 - Desmoglein 1 IgG Ser IA-aCnc
- 94337-3 - Desmoglein 3 IgG Ser IA-aCnc
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube or serum transfer tube
Collection Instructions
Serum samples may be stored for up to eight hours at room temperature before freezing at -20°C. Samples should not be repeatedly frozen and thawed.
Storage Instructions
Frozen at -20°C
Causes for Rejection
Bacterial contamination, hemolysis, lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unstable (stability provided by manufacturer or literature reference) |
| Refrigerated | Unstable (stability provided by manufacturer or literature reference) |
| Frozen | 14 days (stability provided by manufacturer or literature reference) |
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