Pemphigus Antibodies, IgA by IIF

Casandra

Casandra Test Code AR17296Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0092106CPT Codes 88346, 88350

Pemphigus Antibodies, IgA by IIF

Also known as: IGA PEMPHI

Clinical Use

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Use

This test is used to assess and monitor IgA pemphigus or other nonclassical pemphigus subtypes that have both IgA and IgG cell surface antibodies. It is essential for determining the presence of IgA antibodies against desmosomal antigens, using substrates like intact human skin and monkey esophagus. It aids in the diagnosis of IgA pemphigus, which presents as rare subtypes with skin blistering conditions. The test may complement other serological assays for pemphigus diagnosis and monitoring, particularly when correlated with a tissue biopsy and direct immunofluorescence findings.

Special Instructions

Consider ordering concurrently with serum Pemphigus Antibody Panel, IgG (0090650) if other types of pemphigus are suspected. Alternatively, the serum Immunobullous Disease Antibody Panel (3001409) could be considered. Samples less than 0.5 mL require prior communication with the Immunodermatology Laboratory at 801-581-7139.

Limitations

The presence of IgA cell surface antibodies may not be detected in some patients with IgA pemphigus, especially if the disease is minimal or well-controlled. The test does not rule out other immunobullous diseases or more common pemphigoid variants. Clinical correlation with other diagnostic methods, such as direct immunofluorescence, is necessary for comprehensive diagnosis due to overlaps in disease presentations.

Test Details

New York Approved