Pemphigus Antibodies, IgA by IIF
Also known as: IGA PEMPHI
Use
This test is used to assess and monitor IgA pemphigus or other nonclassical pemphigus subtypes that have both IgA and IgG cell surface antibodies. It is essential for determining the presence of IgA antibodies against desmosomal antigens, using substrates like intact human skin and monkey esophagus. It aids in the diagnosis of IgA pemphigus, which presents as rare subtypes with skin blistering conditions. The test may complement other serological assays for pemphigus diagnosis and monitoring, particularly when correlated with a tissue biopsy and direct immunofluorescence findings.
Special Instructions
Not provided.
Limitations
The presence of IgA cell surface antibodies may not be detected in some patients with IgA pemphigus, especially if the disease is minimal or well-controlled. The test does not rule out other immunobullous diseases or more common pemphigoid variants. Clinical correlation with other diagnostic methods, such as direct immunofluorescence, is necessary for comprehensive diagnosis due to overlaps in disease presentations.
New York Approved
Methodology
Immunoassay (Indirect Immunofluorescence)
Biomarkers
LOINC Codes
- 42936-5 - ICS IgA Ser Ql IF
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Storage Instructions
Store refrigerated unless shipping promptly. If stored for more than 14 days, freeze the specimen.
Causes for Rejection
Hemolyzed or lipemic specimens, Plasma.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | Indefinitely |
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