Desmoglein 1 and Desmoglein 3 (Pemphigus) Antibodies, IgG by ELISA

Use

This test is used to monitor disease in individuals diagnosed with various pemphigus variants who have increased IgG desmoglein 1 and/or IgG desmoglein 3 antibodies. The antibody levels correlate with disease activity. ELISA testing for IgG desmoglein 1 and IgG desmoglein 3 antibodies is highly sensitive, with more than 90 percent of patients with IgG-variant pemphigus showing increased levels of one or both antibodies. Specific reactivity to the type of desmoglein helps in determining pemphigus subtypes; increased IgG desmoglein 1 antibody level is associated with pemphigus foliaceus, while increased IgG desmoglein 3 antibody level is associated with pemphigus vulgaris, clinically presenting with mucosal and skin lesions.