Pemphigoid Antibody Panel
Also known as: PGOID PAN
Use
Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial). Useful in diagnosing bullous pemphigoid, epidermolysis bullosa acquisita, linear IgA disease, and dermatitis herpetiformis, which often present with blistering, erosions, pruritus, and urticaria.
Special Instructions
To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410).
Limitations
The negative IgG, including IgG4, and IgA basement membrane zone antibodies, do not rule out the diagnoses of bullous pemphigoid, epidermolysis bullosa acquisita, and linear IgA disease/linear IgA bullous dermatosis. IgG type VII collagen antibody level by ELISA may be more sensitive. Approximately 80% of patients with bullous pemphigoid show positive antibodies in sera, detected by indirect immunofluorescence. Some pemphigoid patients may not have detectable circulating basement membrane zone antibodies.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 48767-8
- 11526-1
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Standard transport tube
Collection Instructions
Transfer serum collected in a plain red or serum separator tube to the transport tube.
Storage Instructions
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days, store and ship refrigerated. If greater than 14 days, store and ship frozen.
Causes for Rejection
Hemolyzed or lipemic specimens. Plasma not acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | Indefinitely |